La forte exposition peut enfin \u00e9galement r\u00e9sulter des propri\u00e9t\u00e9s pharmacocin\u00e9tiques intrins\u00e8ques de l\u2019antibiotique (concentration sp\u00e9cifique de l\u2019antibiotique au site infectieux).<\/li>\n<\/ul>\nLa nouvelle cat\u00e9gorie \u00ab\u00a0Sensible \u00e0 forte posologie\u00a0\u00bb permet ainsi de promouvoir l\u2019utilisation des mol\u00e9cules cat\u00e9goris\u00e9es comme telles et d\u2019\u00e9viter l\u2019utilisation syst\u00e9matique des seules mol\u00e9cules cat\u00e9goris\u00e9es S (par exemple souvent les carbap\u00e9n\u00e8mes) pour les antibiogrammes de souches multi-r\u00e9sistantes.<\/p>\n
<\/p>\n
Promouvoir l’utilisation de certains antibiotiques \u00e0 forte dose<\/h1>\n
Par ailleurs, les ph\u00e9notypes sauvages de certaines esp\u00e8ces bact\u00e9riennes ne sont sensibles \u00e0 certains antibiotiques qu\u2019\u00e0 forte dose. Les nouvelles recommandations nous demandent d’insister sur ce point.<\/p>\n
Pour \u00eatre s\u00fbr de cat\u00e9goriser ces ph\u00e9notypes a minima<\/span> \u00ab Sensibles \u00e0 forte posologie<\/em>\u00bb, les r\u00e8gles de rendu ont \u00e9t\u00e9 modifi\u00e9es, obligeant \u00e0 les rendre comme tels lorsqu\u2019ils ne sont pas R\u00e9sistants. Il ne faut plus rendre ces bact\u00e9ries Sensibles \u00e0 dose standard aux antibiotiques concern\u00e9s, comme nous le faisions jusque l\u00e0.<\/p>\nC’est le cas par exemple de Pseudomonas aeruginosa<\/em> et Pip\u00e9racilline, Pip\u00e9racilline+tazobactam, Ceftazidime ou C\u00e9f\u00e9pime<\/em>.<\/p>\nCela n’implique \u00e9videmment pas que ces antibiotiques ne doivent plus \u00eatre utilis\u00e9s, mais qu’au contraire ils peuvent l’\u00eatre \u00e0 forte posologie<\/span>.<\/p>\nLe CASFM a publi\u00e9 un tableau des propositions europ\u00e9ennes de posologies standard et fortes:\u00a0[ddownload id=\u00a0\u00bb18423″]<\/p>\n
Le CASFM pr\u00e9cise enfin qu’en cas de cystite non compliqu\u00e9e, les mol\u00e9cules \u00e0 \u00e9limination urinaire pr\u00e9dominante cat\u00e9goris\u00e9es non r\u00e9sistantes peuvent \u00eatre utilis\u00e9es \u00e0 dose standard.<\/p>\n
Nous restons \u00e0 votre \u00e9coute en cas de probl\u00e8me sur ce nouveau mode de rendu.<\/p>\n
<\/p>\n
R\u00e9f\u00e9rences: https:\/\/www.sfm-microbiologie.org\/2020\/10\/02\/casfm-eucast-v1-2-octobre-2020\/<\/p>\n","protected":false},"excerpt":{"rendered":"
Les biologistes m\u00e9dicaux de Biolyss actualisent la formulation dans les comptes-rendus d’antibiogramme. Disparition de la cat\u00e9gorie clinique Interm\u00e9diaire Selon les recommandations du Comit\u00e9 de l’Antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie (CASFM), l’ancienne cat\u00e9gorie Interm\u00e9diaire n’existe plus. Les bact\u00e9ries sont … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":55,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1,100,227],"tags":[],"class_list":["post-16876","post","type-post","status-publish","format-standard","hentry","category-actualites","category-actualites-medicales","category-actualites-pro"],"acf":[],"yoast_head":"\nAntibiogramme: la cat\u00e9gorie Interm\u00e9diaire dispara\u00eet - Biolyss<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biolyss.fr\/2022\/12\/06\/antibiogramme-la-categorie-intermediaire-disparait\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibiogramme: la cat\u00e9gorie Interm\u00e9diaire dispara\u00eet - Biolyss\" \/>\n<meta property=\"og:description\" content=\"Les biologistes m\u00e9dicaux de Biolyss actualisent la formulation dans les comptes-rendus d’antibiogramme. 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